Yes, Asheville, NC makes for a superb weekend getaway, but be prepared to cram all the fun into two days. Dubbed the San Francisco of the East Coast, Asheville has a distinct personality mixed with diversity. The culinary scene has risen to the top, serving some of the best BBQ around. The great outdoors is your playground all year long, so hiking, biking, skiing, swimming, fishing, kayaking and any other activity under the sun beckons your arrival. Craft beer is a lifestyle here, with over 15 breweries in town. The beautiful Biltmore Estate is worth a full day of exploration all on its own.